Detailed Pathophysiological Investigation of Canine Pyometra and the Curative Role of Ovariohysterectomy

Background: Pyometra or cystic endometrial hyperplasia complex in dogs is a hormonally mediated bacterial disease wherein middle-aged bitches are most affected. The current study was carried out pyometra-affected to determine the alterations hormonal, histopathological and haemato-biochemical profiles after 14 days of ovariohysterectomy. Methods: Blood samples were collected both from control (n=15) affected showing signs open cervix pyometra preoperatively postoperatively on day surgery, 7th 14th subjected estimation endocrinological hematobiochemical parameters. ovary, oviduct uterus for gross histological observations. Result: pre-operative serum progesterone (ng/ml) recorded with 9-fold higher than controls (9.77±2.64 vs 0.61±0.66) (P less 0.01). There non-significant difference (414.63±62.88) post-operative (390.6±54.20) estrogen concentration results indicated presence an extragonadal source estrogen. enormous lumen these cysts contained eosinophilic hazy granular material tissue debris along massive infiltration inflammatory cells, predominantly neutrophils. findings revealed that major contributory factor sources may be present hyperplastic changes uterine glandular epithelium bitches.